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KMID : 0358420110540060294
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Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 6 p.294 ~ p.299
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Histologic comparison of polycystic ovary syndrome induced by estradiol valerate and letrozole
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Lim Sung-Chul
Jeong Moon-Jin
Kim Se-Eun
Kim Seung-Hyun
Kim Sam-Cheol
Seo Seung-Yong
Kim Tak
Kang Sung-Soo
Bae Chun-Sik
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Abstract
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Objective : To compare ovarian morphology of the estradiol valerate (EV)- and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models.
Methods: EV were injected (IM) to 10 Sprague-Dawley rats and LE were administered (PO) to the other 10 Sprague-Dawley rats for 21 days. Sixty days after single injection of EV and 21 days after LE administration, the animals were sacrificed and the ovaries were sectioned, measured and analyzed histopathologically.
Results: LE-treated group showed larger ovary bearing more abundant cystic follicles with luteinized theca cells. These findings were more similar to human PCOS ovarian morphology.
Conclusion: LE-induced PCOS model is recommended to conduct PCOS-related animal experiments.
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KEYWORD
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Polycystic ovary syndrome, Estradiol valerate, Letrozole, Ovary
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